{"id":22587,"date":"2023-09-13T12:29:17","date_gmt":"2023-09-13T10:29:17","guid":{"rendered":"https:\/\/p698827.webspaceconfig.de\/2023\/09\/13\/sense-and-nonsense-of-yt-staging-on-mri-after-chemoradiotherapy-in-rectal-cancer\/"},"modified":"2026-03-25T17:01:21","modified_gmt":"2026-03-25T16:01:21","slug":"sense-and-nonsense-of-yt-staging-on-mri-after-chemoradiotherapy-in-rectal-cancer","status":"publish","type":"post","link":"https:\/\/www.bauer-diagnostics.com\/hu\/2023\/09\/13\/sense-and-nonsense-of-yt-staging-on-mri-after-chemoradiotherapy-in-rectal-cancer\/","title":{"rendered":"SENSE AND NONSENSE OF YT-STAGING ON MRI AFTER CHEMORADIOTHERAPY IN RECTAL CANCER"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"22587\" class=\"elementor elementor-22587 elementor-22518\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-60121b0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"60121b0\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-e14321e\" data-id=\"e14321e\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-619dd07 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"619dd07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-calendar\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">2023.09.13.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-03ef623 elementor-widget elementor-widget-heading\" data-id=\"03ef623\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">SENSE AND NONSENSE OF YT-STAGING ON MRI AFTER CHEMORADIOTHERAPY IN RECTAL CANCER<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-98a281b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"98a281b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-custom\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-686cd08\" data-id=\"686cd08\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b52acfd elementor-widget elementor-widget-image\" data-id=\"b52acfd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"492\" height=\"492\" src=\"https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/Veroeff_07.webp\" class=\"attachment-large size-large wp-image-24952\" alt=\"\" srcset=\"https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/Veroeff_07.webp 492w, https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/Veroeff_07-300x300.webp 300w, https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/Veroeff_07-150x150.webp 150w, https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/Veroeff_07-230x230.webp 230w, https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/Veroeff_07-400x400.webp 400w\" sizes=\"(max-width: 492px) 100vw, 492px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-8018f6e\" data-id=\"8018f6e\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a7c6ca0 elementor-widget elementor-widget-image\" data-id=\"a7c6ca0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"371\" height=\"371\" src=\"https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/SpringerLink-logo-660x371-1.webp\" class=\"attachment-large size-large wp-image-24953\" alt=\"\" srcset=\"https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/SpringerLink-logo-660x371-1.webp 371w, https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/SpringerLink-logo-660x371-1-300x300.webp 300w, https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/SpringerLink-logo-660x371-1-150x150.webp 150w, https:\/\/www.bauer-diagnostics.com\/wp-content\/uploads\/2023\/09\/SpringerLink-logo-660x371-1-230x230.webp 230w\" sizes=\"(max-width: 371px) 100vw, 371px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-23507d5 elementor-widget elementor-widget-text-editor\" data-id=\"23507d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Dr. Ferdinand Bauer is a co-author of this article and responsible for Investigation; Writing \u2013 review &amp; editing<\/strong><\/p>\n<h3 class=\"title\">ABSTRACT<\/h3>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Aim: <br \/><\/strong>The aim of this work was to investigate the value of rectal cancer T-staging on MRI after chemoradiotherapy (ymrT-staging) in relation to the degree of fibrotic transformation of the tumour bed as assessed using the pathological tumour regression grade (pTRG) of Mandard as a standard of reference.<\/p>\n<p><strong class=\"sub-title\">Method: <br \/><\/strong>Twenty two radiologists, including five rectal MRI experts and 17 \u2019nonexperts\u2018 (general\/abdominal radiologists), evaluated the ymrT stage on the restaging MRIs of 90 rectal cancer patients after chemoradiotherapy. The ymrT stage was compared with the final ypT stage at histopathology; the percentages of correct staging (ymrT = ypT), understaging (ymrT &lt; ypT) and overstaging (ymrT &gt; ypT) were calculated and compared between patients with predominant tumour at histopathology (pTRG4-5) and patients with predominant fibrosis (pTRG1-3). Interobserver agreement (IOA) was computed using Krippendorff\u2019s alpha.<\/p>\n<p><strong class=\"sub-title\">Results:<br \/><\/strong>Average ymrT\/ypT stage concordance was 48% for the experts and 43% for the nonexperts; ymrT\/ypT stage concordance was significantly higher in the pTRG4-5 subgroup (58% vs. 41% for the pTRG1-3 group; p = 0.01), with the best results for the MRI experts. Overstaging was the main source of error, especially in the pTRG1-3 subgroup (average overstaging rate 38%-44% vs. 13%-55% in the pTRG4-5 subgroup). IOA was higher for the expert versus nonexpert readers (\u03b1 = 0.67 vs. \u03b1 = 0.39).<\/p>\n<p><strong class=\"sub-title\">Conclusions: <br \/><\/strong>ymrT-staging is moderately accurate; accuracy is higher in poorly responding patients with predominant tumour but low in good responders with predominant fibrosis, resulting in significant overstaging. Radiologists should shift their focus from ymrT-staging to detecting gross residual (and progressive) disease, and identifying potential candidates for organ preservation who would benefit from further clinical and endoscopic evaluation to guide final treatment planning.<\/p>\n<\/div>\n<p>This medical abstract is published in the following media:<\/p>\n<p><strong>Published in:<\/strong><\/p>\n<p><strong>Colorectal Disease 2023 Aug 6. doi: 10.1111\/codi.16698<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37545140\/\" target=\"_blank\" rel=\"noopener\"><em><strong>National Library of Medicine<\/strong><\/em><\/a><br \/><strong><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.16698\" target=\"_blank\" rel=\"noopener\"><em>WILEY Online library<\/em><\/a><\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-0f01159\" data-id=\"0f01159\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f4acb81 elementor-widget elementor-widget-heading\" data-id=\"f4acb81\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Kiadv\u00e1nyok<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Dr. Ferdinand Bauer is a co-author of this article and responsible for Investigation; Writing \u2013 review &amp; editing ABSTRACT Aim: The aim of this work was to investigate the value of rectal cancer T-staging on MRI after chemoradiotherapy (ymrT-staging) in relation to the degree of fibrotic transformation of the tumour bed as assessed using the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":22573,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[350],"tags":[],"class_list":["post-22587","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kiadvanyok"],"_links":{"self":[{"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/posts\/22587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/comments?post=22587"}],"version-history":[{"count":5,"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/posts\/22587\/revisions"}],"predecessor-version":[{"id":26934,"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/posts\/22587\/revisions\/26934"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/media\/22573"}],"wp:attachment":[{"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/media?parent=22587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/categories?post=22587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bauer-diagnostics.com\/hu\/wp-json\/wp\/v2\/tags?post=22587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}